منابع مشابه
Neurotoxicity of intrathecal methotrexate: MR imaging findings.
We report a case of intrathecal methotrexate neurotoxicity manifesting as left arm weakness and aphasia. Diagnostic imaging showed restricted diffusion and fluid-attenuated inversion recovery imaging findings were normal at presentation. Three weeks later, diffusion abnormalities resolved, and T2-weighted studies showed increased signal intensity of prolonged T2 changes in areas of prior restri...
متن کاملDiffusion-weighted MR imaging of early methotrexate-related neurotoxicity in children.
BACKGROUND AND PURPOSE Methotrexate is a major cause of treatment-related acute neurotoxicity in children with hematologic malignancies. The purpose of this study was to investigate whether diffusion-weighted MR imaging (DWI) detects acute methotrexate white matter neurotoxicity in this patient population. METHODS Six children-three female and three male-with hematologic malignancies were stu...
متن کاملChemotherapy-Related Neurotoxicity.
Chemotherapy may have detrimental effects on either the central or peripheral nervous system. Central nervous system neurotoxicity resulting from chemotherapy manifests as a wide range of clinical syndromes including acute, subacute, and chronic encephalopathies, posterior reversible encephalopathy, acute cerebellar dysfunction, chronic cognitive impairment, myelopathy, meningitis, and neurovas...
متن کاملImpact of Physalis angulata on Methotrexate-Induced Neurotoxicity
Oxidative stress contributes in the pathogenesis of methotrexate (MTX)-induced damage in the various organs. Many agents have been tested experimentally to reduce or inhibit the oxidative stress. However, the possible protective effect of Physalis angulata extract (PAE) on MTX-induced neurotoxicity in male rats and the mechanisms by which this plant exerts its beneficial effects is unknown.Male...
متن کاملA woman who couldn't speak: report of methotrexate neurotoxicity.
The association between methotrexate therapy and idiosyncratic neurological complications is well recognised in children. This case illustrates the importance of considering the diagnosis of methotrexate toxicity in an adult patient with behavioural and speech disturbances, who received it by intrathecal route only and in whom the only indicator was an abnormal electroencephalographic study.
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ژورنال
عنوان ژورنال: Pediatric Radiology
سال: 2010
ISSN: 0301-0449,1432-1998
DOI: 10.1007/s00247-010-1629-3